Lymphotoxin production by lymphocytes from leprosy patients.
نویسندگان
چکیده
منابع مشابه
Lymphocyte transfer reactions in leprosy patients.
We have demonstrated that allograft immunity is impaired in leprosy patients, especially patients with lepromatous leprosy ( 4). This finding indicates that the lymphocytes of leprosy patients are immunologically defective with respect to their activities in vivo, a concept which is supported by the in vitro work of others on lymphocyte transformation (2, 3, 8), and our recent work on lymphotox...
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Although the production of lymphotoxin (LT) from activated Th1 lymphocytes has been reported extensively, the intracellular signaling mechanisms that regulate this T cell function remain totally undefined. We have examined whether the p21ras-raf-1-mitogen-activated protein kinase/extracellular signal-regulated protein kinase (ERK) kinase (MEK)-ERK cascade plays a role in regulating the producti...
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In order to understand the mechanism of unresponsiveness towards Mycobacterium leprae antigens in leprosy, we evaluated the role of M. leprae sonicate antigens in regulating the expression of the costimulatory molecules B7-1, CD28, intercellular adhesion molecule-1 (ICAM-1), LFA-1alpha, LFA-1beta and Mac-1 on the lymphocytes of both leprosy patients and healthy subjects. It was observed that th...
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عنوان ژورنال:
- International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
دوره 39 3 شماره
صفحات -
تاریخ انتشار 1971